Description

(2S)-2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Prop-2-Ynyl-Amino]Benzoyl]Amino]Pentanedioic Acid is a high-purity, structurally complex folate analog and biochemical intermediate. This compound matters for its role in advanced research and development, particularly in the study of enzyme inhibition and metabolic pathways. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers focused on developing novel therapeutics and diagnostic agents.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel antifolate drugs and enzyme inhibitors.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies, particularly those involving folate-dependent enzymes and one-carbon metabolism pathways.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis (HPLC, LC-MS).
• Preclinical Studies: Utilized in in vitro and in vivo research models to investigate mechanisms of action, pharmacokinetics, and efficacy of potential therapeutic compounds.
• Diagnostic Agent Development: Acts as a precursor or component in the development of specialized diagnostic assays and probes.
• Fine Chemical Synthesis: A valuable building block for the custom synthesis of more complex, target-specific molecules for specialized applications.

Basic Information

Item	Details
Product Name	(2S)-2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Prop-2-Ynyl-Amino]Benzoyl]Amino]Pentanedioic Acid
CAS No.	101760-45-6
Molecular Formula	C23H23N7O6
Molecular Weight	493.47 g/mol
Synonyms	6-[(Prop-2-yn-1-yl){4-[(2S)-2,5-dicarboxypentanamido]benzoyl}amino]methyl]-2-amino-1,4-dihydro-4-oxopteridine; LY309887 analog; Pteroylglutamate derivative; Antifolate intermediate; Glutamate-linked pteridine; Tetrahydrofolate synthesis inhibitor intermediate; (S)-2-(4-((((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)(prop-2-yn-1-yl)amino)benzamido)pentanedioic acid
EINECS	Contact for details

Quality Control

Our production of (2S)-2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Prop-2-Ynyl-Amino]Benzoyl]Amino]Pentanedioic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. All materials are subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing specific test results is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.