Description

4-[2-[3-[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]aminopropanoylamino]ethylsulfanyl]-2-hydroxy-4-oxo-butanoic acid is a complex, high-purity biochemical intermediate of significant importance in advanced pharmaceutical research and development. Its intricate structure, featuring a modified nucleotide core linked to a lipoic acid derivative via a peptide bond, makes it a critical precursor for synthesizing novel coenzyme A analogs and targeted prodrugs. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on metabolic pathway modulation, enzyme-targeted therapies, and next-generation nucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of novel coenzyme A (CoA) derivatives and analogs with potential therapeutic applications.
• Biochemical Research: Used as a critical reagent in studying enzymatic pathways, particularly those involving acyl-CoA synthetases and transferases, for target identification and validation.
• Prodrug Development: Acts as a sophisticated carrier moiety in the design of targeted prodrugs, leveraging its structure for improved cellular uptake and site-specific activation.
• Metabolic Studies: Employed in research focused on lipid metabolism, energy regulation, and mitochondrial function due to its role as a potential CoA precursor.
• Enzyme Inhibition Studies: Utilized to investigate and develop inhibitors for specific enzymes within the CoA biosynthesis and utilization pathways.
• High-Value Fine Chemical Synthesis: Integral in multi-step synthetic routes for producing specialized nucleotides and complex bioactive molecules for preclinical development.

Basic Information

Product Name	4-[2-[3-[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]aminopropanoylamino]ethylsulfanyl]-2-hydroxy-4-oxo-butanoic acid
CAS No.	2043-93-8
Molecular Formula	C28H44N7O20P3S
Molecular Weight	923.66 g/mol
Synonyms	Deoxyadenosine triphosphate lipoate analog; DATP-Lipoic acid conjugate; Adenine nucleotide-lipoamide conjugate; Coenzyme A analog precursor; 3'-Deoxy-ATP lipoic acid derivative; [[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[hydroxy-[3-[[2-[2-(1,2-dithiolan-3-yl)acetamido]ethoxy]-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]oxy]hydroxyphosphoryl] hydrogen phosphate; Lipoic acid-adenosine triphosphate hybrid molecule
EINECS	Contact for details

Quality Control

This high-value biochemical is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for research and development. Production adheres to cGMP guidelines where applicable. Identity, purity, and impurity profiles are rigorously confirmed using advanced analytical techniques including HPLC, LC-MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing assay, purity, and related substances is provided with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm
Bacterial Endotoxins	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.