Description

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]amino]-2-oxoethyl]-, 1,4,7-tris(1,1-dimethylethyl) ester is a sophisticated, multi-functional chelating agent and a key intermediate in advanced chemical synthesis. This compound is engineered for the site-specific conjugation of biomolecules, offering a versatile platform for creating targeted diagnostic and therapeutic agents. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and medical imaging sectors who require high-purity, functionalized macrocyclic platforms.

Application

• Bioconjugation Reagent: Primary application for attaching peptides, proteins, antibodies, or oligonucleotides via its maleimide-reactive group for targeted drug delivery systems.
• Radiopharmaceutical Precursor: Critical intermediate in the synthesis of bifunctional chelators used to complex diagnostic (e.g., 68Ga, 64Cu) or therapeutic (e.g., 177Lu, 225Ac) radiometals for PET/SPECT imaging and targeted radionuclide therapy.
• Contrast Agent Development: Used in the research and production of next-generation MRI contrast agents by providing a stable macrocyclic scaffold for gadolinium or other lanthanide ions.
• Fluorescent Probe Synthesis: Serves as a linker to attach fluorophores to targeting molecules for in vitro and in vivo fluorescence imaging and assays.
• Drug Discovery & Development: Employed in creating antibody-drug conjugates (ADCs) and other targeted therapeutics where precise chemical linkage is required.
• Catalyst Ligand Synthesis: Potential use as a precursor for developing specialized ligands in homogeneous catalysis and material science.

Basic Information

Item	Details
Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]amino]-2-oxoethyl]-, 1,4,7-tris(1,1-dimethylethyl) ester
CAS No.	1613382-10-7
Molecular Formula	C37H62N6O10
Molecular Weight	726.93 g/mol
Synonyms	DOTA-tris(t-Bu ester)-Maleimide; Maleimide-DOTA-tris(t-butyl ester); 2,2',2''-(10-(2-((2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid tris(1,1-dimethylethyl) ester; 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid-10-maleimide, tris(t-butyl) ester; Maleimide monoamide-tris(t-butyl)-DOTA; Bifunctional Chelator DOTA-Maleimide (t-Bu ester); DOTA-Mal (t-Bu)3; DOTA-tris(t-Bu ester) Maleimide Conjugate
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for sensitive bioconjugation applications. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each batch to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant to maintain stability due to its hygroscopic and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.