Description

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,1'-(1,2-ethanediyl) 5,5'-dimethyl ester 4-methylbenzenesulfonate is a complex, high-purity chemical intermediate with significant value in advanced pharmaceutical research and development. Its intricate molecular structure, featuring a pyrrolopyrimidine core linked to a glutamic acid derivative, makes it a critical building block for the synthesis of novel therapeutic agents. This compound is primarily targeted at pharmaceutical companies and advanced research institutions engaged in oncology and targeted therapy development, where precise molecular control is paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antifolate drugs and targeted chemotherapeutic agents.
• Anticancer Drug Research: Used in the development of compounds that inhibit specific enzymes involved in cancer cell proliferation, such as thymidylate synthase.
• Biochemical Research: Serves as a tool compound for studying folate metabolism and enzyme inhibition pathways in vitro.
• Active Pharmaceutical Ingredient (API) Development: Employed in the research-scale synthesis of potential new chemical entities (NCEs) for preclinical evaluation.
• Process Chemistry: Used by process development teams to optimize scalable synthetic routes for complex drug molecules.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,1'-(1,2-ethanediyl) 5,5'-dimethyl ester 4-methylbenzenesulfonate
CAS No.	1158917-06-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Pemetrexed Impurity; Pemetrexed Disater; Pemetrexed Related Compound; L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, 1-(1,2-ethanediyl) 5,5'-dimethyl ester, 4-methylbenzenesulfonate (1:1); ALIMTA Impurity; 1158917-06-6; Antifolate Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.