Description

(2S,4S,5R,6R)-5-acetamido-2-[4-[(5-dimethylaminonaphthalen-1-yl)sulfon ylamino]phenyl]sulfanyl-4-hydroxy-6-[(1S,2R)-1,2,3-trihydroxypropyl]ox ane-2-carboxylic acid CAS NO 141303-70-0 is a sophisticated, high-purity chemical building block featuring a dansyl fluorophore conjugated to a modified sugar acid core. This compound is engineered for advanced research and development, offering a unique combination of fluorescence properties and specific molecular recognition. It is primarily utilized by scientists and process developers in the pharmaceutical and biotechnology sectors for creating novel probes, diagnostic agents, and targeted therapeutic conjugates.

Application

• Fluorescent Labeling Reagent: Acts as a sensitive dansyl-based probe for labeling biomolecules (e.g., proteins, peptides, antibodies) for detection and quantification assays.
• Bioconjugation Intermediate: Serves as a key synthetic intermediate for the development of antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Diagnostic Agent Development: Used in research for designing fluorescence-based diagnostic kits and imaging agents for cellular and in vitro studies.
• Enzyme Substrate/Analog: Potential application as a substrate or inhibitor in enzymatic studies, particularly those involving glycosidases or related enzymes, due to its sugar-like structure.
• Chemical Biology Research: Employed as a tool compound to study carbohydrate-protein interactions, cell surface labeling, and intracellular trafficking mechanisms.
• High-Throughput Screening (HTS): Can be incorporated into assay development for drug discovery screens targeting specific biological pathways.

Basic Information

Item	Details
Product Name	(2S,4S,5R,6R)-5-acetamido-2-[4-[(5-dimethylaminonaphthalen-1-yl)sulfon ylamino]phenyl]sulfanyl-4-hydroxy-6-[(1S,2R)-1,2,3-trihydroxypropyl]ox ane-2-carboxylic acid
CAS No.	141303-70-0
Molecular Formula	C30H35N3O10S2
Molecular Weight	661.74 g/mol
Synonyms	5-Acetamido-2-[[4-[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]thio]-4-hydroxy-6-[(1S,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid; Dansyl-labeled thioglycoside derivative; N-[5-(Dimethylamino)naphthalene-1-sulfonyl]-S-(4-aminophenyl) conjugate; Fluorescent glycosyl probe; 1-Dansylamido-4-thiophenyl glycoside acid; CAS 141303-70-0
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and MS analyses. We support development and cGMP manufacturing needs with a commitment to traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.