Description

6-O-(2-deoxy-3-O-(3-hydroxytetradecanoyl)-2-((3-hydroxytetradecanoyl)amino)-glycopyranosyl)-2-deoxy-3-O-(3-hydroxytetradecanoyl)-2-((3-hydroxytetradecanoyl)amino)-glucopyranosylphosphonate is a complex, high-purity synthetic lipid A derivative and a key intermediate in advanced pharmaceutical research. This compound is critical for studying and modulating the innate immune response, specifically targeting Toll-like receptor 4 (TLR4) pathways. It is essential for researchers and developers in immunology, vaccine adjuvants, and novel therapeutic discovery, where precise molecular tools are required to investigate inflammatory and immune-modulating mechanisms.

Application

• Immunological Research: A vital tool for studying TLR4-mediated signaling pathways, macrophage activation, and cytokine production.
• Vaccine Adjuvant Development: Serves as a synthetic analog for developing next-generation adjuvants to enhance vaccine efficacy and safety profiles.
• Inflammation & Sepsis Models: Used in preclinical research to model and investigate therapeutic interventions for septic shock and chronic inflammatory diseases.
• Structure-Activity Relationship (SAR) Studies: Enables the exploration of lipid A mimetics to fine-tune immunostimulatory or antagonistic properties.
• Bioconjugation & Probe Synthesis: Acts as a sophisticated building block for creating labeled probes or conjugates for cellular and molecular imaging studies.
• Pharmaceutical Intermediate: Employed in the synthesis of more complex immunomodulatory candidates and novel drug entities.

Basic Information

Product Name	6-O-(2-deoxy-3-O-(3-hydroxytetradecanoyl)-2-((3-hydroxytetradecanoyl)amino)-glycopyranosyl)-2-deoxy-3-O-(3-hydroxytetradecanoyl)-2-((3-hydroxytetradecanoyl)amino)-glucopyranosylphosphonate
CAS No.	131061-35-3
Molecular Formula	C68H128N2O23P
Molecular Weight	1381.75 g/mol
Synonyms	Lipid A Precursor Analog; Synthetic Lipid A Derivative; TLR4 Ligand Intermediate; 6-O-[2-Deoxy-3-O-(3-hydroxytetradecanoyl)-2-[(3-hydroxytetradecanoyl)amino]-α-D-glucopyranosyl]-2-deoxy-3-O-(3-hydroxytetradecanoyl)-2-[(3-hydroxytetradecanoyl)amino]-α-D-glucopyranosyl 1-Phosphonate; Glucopyranosylphosphonate Lipid A Mimetic; Monophosphoryl Lipid A (MPLA) Synthetic Intermediate; Hexaacyl Lipid A Analog
EINECS	Contact for details

Quality Control

Our 6-O-(2-deoxy-3-O-(3-hydroxytetradecanoyl)-2-((3-hydroxytetradecanoyl)amino)-glycopyranosyl)-2-deoxy-3-O-(3-hydroxytetradecanoyl)-2-((3-hydroxytetradecanoyl)amino)-glucopyranosylphosphonate is manufactured under strict quality systems to ensure batch-to-batch consistency and purity for critical research applications. All materials are supported by comprehensive analytical data, including HPLC purity, NMR structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms (M+H)+
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.