Description

[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid is a sophisticated, high-purity nucleotide derivative designed for advanced research and development. This compound is critical for applications requiring precise molecular structure and high biochemical activity, particularly in the development of novel therapeutic agents and diagnostic tools. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on nucleotide-based drug discovery and biochemical mechanism studies.

Application

• Pharmaceutical Research & Development: As a key intermediate or building block in the synthesis of novel nucleotide-based therapeutics, including potential antiviral or anticancer agents.
• Biochemical Probes & Diagnostics: For the development of highly specific probes, enzyme substrates, or diagnostic markers in molecular biology and clinical research.
• Antisense Oligonucleotide Synthesis: Serving as a modified nucleoside phosphonate monomer for the solid-phase synthesis of advanced antisense or siRNA oligonucleotides.
• Enzyme Mechanism Studies: Used as a substrate or inhibitor to study the kinetics and mechanisms of specific kinases, polymerases, or other nucleotide-processing enzymes.
• Prodrug Development: Acting as a precursor in the design of nucleotide prodrugs aimed at improving cellular uptake and metabolic stability.
• High-Value Chemical Reference Standard: Providing a certified standard for quality control and analytical method development in pharmaceutical manufacturing.

Basic Information

Product Name	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
CAS No.	119785-99-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Adenosine derivative phosphonic acid; Modified nucleoside phosphonate; 9H-Purin-6-amine, 9-[(2R,3S,4R,5R)-5-[[[[[3-[[2-[[2-[(1E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]thio]ethyl]amino]-2-oxoethyl]amino]-3-hydroxy-2,2-dimethylpropoxy]hydroxyphosphinyl]oxy(hydroxy)phosphinyl]oxymethyl]-3,4-dihydroxyoxolan-2-yl]-; Nucleotide prodrug intermediate; Acyclic nucleoside phosphonate analog; ANP derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this high-value nucleotide derivative adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet the requirements of cGMP, ICH guidelines, and research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.