Description

22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)-44-O-de[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]-10-dechlorovancomycin is a structurally complex glycopeptide derivative of vancomycin, representing a key intermediate in the development of next-generation antibiotics. This compound is of significant interest for its potential to address bacterial resistance mechanisms and for use in advanced pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis and evaluation of novel antimicrobial agents.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate in the synthesis of novel semi-synthetic glycopeptide antibiotics aimed at overcoming vancomycin resistance.
• Antimicrobial Mechanism Studies: Used as a reference standard or probe in biochemical assays to study bacterial cell wall synthesis and the binding interactions of advanced glycopeptides.
• Medicinal Chemistry: Provides a sophisticated scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties and antibacterial potency.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for the production of next-generation antibiotic candidates.
• Analytical Standard: Used as a high-purity standard in HPLC, LC-MS, and NMR for quality control and method validation in related API manufacturing.

Basic Information

Product Name	22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)-44-O-de[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]-10-dechlorovancomycin
CAS No.	111073-22-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	10-Dechlorovancomycin derivative; 10-Dechloro-vancomycin aglycon derivative; Dechlorovancomycin intermediate; (α-L-Arabino-hexopyranosyl, α-L-lyxo-hexopyranosyl)-10-dechlorovancomycin derivative; Antibiotic intermediate 111073-22-4; Glycopeptide antibiotic intermediate; Semi-synthetic vancomycin analog
EINECS	Contact for details

Quality Control

This high-value pharmaceutical intermediate is produced under strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, LC-MS, and NMR to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.