Description

Thiostrepton CAS NO 1393-48-2 is a sulfur-containing, macrocyclic polypeptide antibiotic produced by *Streptomyces azureus*. This compound is a critical research tool and active pharmaceutical ingredient valued for its potent activity against Gram-positive bacteria, particularly in veterinary medicine and microbiological research. It is essential for manufacturers and R&D laboratories in the pharmaceutical, veterinary, and life science sectors requiring a high-purity, reliable antibiotic for formulation, mechanism-of-action studies, and quality control applications.

Application

• Veterinary Pharmaceutical Formulations: A key active ingredient in topical ointments and injectables for treating mastitis and other bacterial infections in livestock.
• Microbiological Research & Assay Development: Used as a selective agent in culture media and in studies of bacterial protein synthesis, specifically targeting the 50S ribosomal subunit.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control testing in pharmaceutical manufacturing and regulatory compliance.
• Biochemical Pathway Inhibition: Employed in molecular biology to inhibit thiostrepton-induced genes and study regulatory mechanisms in *Streptomyces* and other actinobacteria.
• Antibiotic Resistance Studies: Utilized in research investigating bacterial resistance mechanisms to peptide antibiotics.
• Cell Culture & Fermentation: Acts as an additive in specific fermentation processes and cell culture systems to prevent bacterial contamination from Gram-positive organisms.

Basic Information

Product Name	Thiostrepton
CAS No.	1393-48-2
Molecular Formula	C72H85N19O18S5
Molecular Weight	1664.9 g/mol
Synonyms	Thiostrepton; Bryamycin; Thiactin; Alanosin; Alanosine; Antibiotic 1393-48-2; Abbott 47725; NSC 115973; SQ 15859; EINECS 215-742-2
EINECS	215-742-2

Quality Control

Our Thiostrepton is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent limits for related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccant in the container and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to yellowish-brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.