Description

Colistin is a critically important polypeptide antibiotic belonging to the polymyxin class, primarily used as a last-resort treatment for multidrug-resistant Gram-negative bacterial infections. Its value lies in its potent bactericidal activity against pathogens like *Pseudomonas aeruginosa*, *Acinetobacter baumannii*, and *Klebsiella pneumoniae*, where other antibiotics have failed. This product is essential for the pharmaceutical industry in the formulation of injectable and topical medications, as well as for veterinary medicine and research applications in microbiology and pharmacology.

Application

• Human Pharmaceutical Formulations: A key active pharmaceutical ingredient (API) in injectable solutions for treating severe, hospital-acquired infections caused by multidrug-resistant Gram-negative bacteria.
• Veterinary Medicine: Used in the treatment of enteric and systemic infections in livestock, poultry, and companion animals, often formulated in premixes, oral solutions, or injectables.
• Microbiological Research: Serves as a selective agent in culture media and as a critical tool in studies of bacterial resistance mechanisms, pharmacokinetics, and pharmacodynamics.
• Topical Preparations: Incorporated into ointments, creams, and powders for the treatment of skin, ear, and eye infections where localized polymyxin therapy is indicated.
• Combination Therapies: Used in synergistic antibiotic combinations to enhance efficacy and combat emerging pan-drug resistant bacterial strains.

Basic Information

Product Name	Colistin
CAS No.	1066-17-7
Molecular Formula	C52H98N16O13
Molecular Weight	1155.45 g/mol
Synonyms	Polymyxin E; Colistin Sulfate (common salt form); Colimycin; Coly-Mycin; Colisticin; Multimycin; Colistin A; Colistin B; [5S-[5R*,8S*,9S*,16R*]]-N5-[Amino(1-oxopentyl)amino]butyl]-L-2,4-diaminobutanoyl-L-threonyl-D-leucyl-L-α,γ-diaminobutanoyl-L-leucyl-L-α,γ-diaminobutanoyl-L-threonyl-L-α,γ-diaminobutanoic acid cyclic (8→1) peptide
EINECS	213-891-1

Quality Control

Our Colistin is manufactured and tested under a strict quality management system. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical applications, with specifications typically referencing major pharmacopoeias. Certificates of Analysis (COA) documenting purity, potency, identity, and related substances are provided to ensure traceability and compliance with your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to slightly yellow powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	≥ 77.0% (as Colistin Base)
Potency	≥ 19,000 IU/mg
pH (1% Solution)	4.0 - 6.5
Loss on Drying	≤ 7.0 %
Related Substances (HPLC)	Meets acceptance criteria
Residual Solvents	Complies with ICH guidelines
Bacterial Endotoxins	< 0.05 EU/IU
Sterility (if applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.