Description

Polymyxin B Sulfate is a potent polypeptide antibiotic complex derived from *Bacillus polymyxa*. This compound is critically important for its bactericidal activity against a wide range of Gram-negative pathogens, particularly those resistant to other antibiotic classes. It is an essential raw material for the pharmaceutical industry, primarily used in the formulation of injectable and topical medications to treat serious systemic and localized infections.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of injectable antibiotic formulations for hospital use.
• Topical Preparations: Used in ointments, creams, and eye/ear drops for treating skin, ocular, and otic infections.
• Veterinary Medicine: Employed in treatments for bacterial infections in livestock and companion animals.
• Combination Therapies: Often formulated with other antibiotics (e.g., bacitracin, neomycin) to broaden the antimicrobial spectrum.
• Research & Development: Serves as a critical reference standard and tool in microbiological research and antibiotic resistance studies.
• Cell Culture Applications: Used in selective media to prevent bacterial contamination in biotechnological processes.

Basic Information

Product Name	Polymyxin B Sulfate
CAS No.	1405-20-5
Molecular Formula	Contact for details
Molecular Weight	~1,300 g/mol (as a mixture)
Synonyms	Polymyxin B Sulphate; Aerosporin; Polyfax; Polymyxin B; Polymixin B Sulfate; Polymyxin B1 Sulfate; Polymyxin B2 Sulfate; Antibiotic B 50
EINECS	215-774-7

Quality Control

Our Polymyxin B Sulfate is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to ensure identity, purity, potency, and safety, with compliance aligned to relevant pharmacopoeial monographs. A comprehensive Certificate of Analysis (COA) detailing specific test results for each batch is provided to guarantee traceability and consistency for our B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 6,500 IU/mg (on dried basis)
Loss on Drying	≤ 7.0 %
pH (1% Solution)	5.0 - 7.5
Related Substances (HPLC)	Meets requirement
Bacterial Endotoxins	< 0.5 EU/mg
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.