Description

Polymyxin B, n-Sulfomethyl Deriv., Sodium Salt is a chemically modified derivative of the polypeptide antibiotic polymyxin B, designed to enhance solubility and potentially reduce nephrotoxicity. This compound is of significant interest for its antimicrobial activity, particularly against Gram-negative bacteria. It is primarily utilized by pharmaceutical researchers and manufacturers in the development of novel therapeutic agents and as a critical reference standard in quality control laboratories.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the research and synthesis of new antibiotic formulations and combination therapies.
• Reference Standard: Used in analytical laboratories for the identification, assay, and purity testing of polymyxin-based products via HPLC, microbiological assays, or other pharmacopeial methods.
• Microbiological Research: Employed in studies investigating mechanisms of action, bacterial resistance, and structure-activity relationships (SAR) of polymyxin-class antibiotics.
• API Development: Investigated for use in the development of Active Pharmaceutical Ingredients (APIs) with improved safety profiles for systemic or topical administration.
• Veterinary Medicine: Potential application in the development of antimicrobial treatments for animal health.

Basic Information

Product Name	Polymyxin B, n-Sulfomethyl Deriv., Sodium Salt
CAS No.	1407-09-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Sulfomethylpolymyxin B Sodium Salt; Sodium Polymyxin B Sulfomethylate; N-Sulfomethylpolymyxin B Sodium; Polymyxin B Methanesulfonate Sodium Salt; Polymyxin B Sulfomethylate Sodium; Polymyxin B Sulphomethylate Sodium Salt; Polymyxin B, Sulfomethylated, Sodium Salt
EINECS	Contact for details

Quality Control

Our Polymyxin B, n-Sulfomethyl Deriv., Sodium Salt is manufactured and tested under a rigorous quality management system. Each batch is analyzed to ensure identity, purity, and consistency. While specific grades can be produced, our standard offering is suitable for research and development purposes. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
pH (Solution)	6.0 - 8.0
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.