Description

Gramicidin C is a naturally occurring, linear polypeptide antibiotic belonging to the gramicidin family. This compound is valued for its potent antimicrobial activity, particularly against Gram-positive bacteria, by forming ion channels in cell membranes. It is a critical raw material and research standard for the pharmaceutical, biotechnology, and life science industries. Key applications include its use in topical formulations, as a biochemical research tool, and in studies of ion channel function.

Application

• Pharmaceutical Intermediates: Serves as a key active pharmaceutical ingredient (API) or intermediate in the formulation of topical antibiotic creams, ointments, and ophthalmic solutions.
• Biochemical Research: Used extensively as a research tool in microbiology and biophysics to study mechanisms of antimicrobial action and ion transport across lipid bilayers.
• Combination Therapies: Employed in combination with other antibiotics like neomycin and polymyxin B in broad-spectrum topical preparations for skin and eye infections.
• Veterinary Medicine: Incorporated into topical treatments for bacterial infections in animals.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, and other chromatographic methods.
• Cell Biology Studies: Applied in experimental protocols to modulate membrane potential and permeability in cellular and molecular biology research.

Basic Information

Product Name	Gramicidin C
CAS No.	113-73-5
Molecular Formula	C~99~H~140~N~20~O~17~
Molecular Weight	~1882.3 g/mol
Synonyms	Gramicidin C; Gramicidin C1; Gramicidin C-1; Gramicidin C Component; Gramicidin C Mixture; Gramicidin C from Bacillus brevis; Gramicidin C (Polymyxin); Gramicidin C (Antibiotic)
EINECS	204-028-2

Quality Control

Our Gramicidin C is manufactured and tested under strict quality management systems. Each batch undergoes comprehensive analysis to ensure identity, purity, and potency, meeting the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) detailing specifications and test results are provided with every shipment. We can supply material compliant with various pharmacopeial standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0 %
Residue on Ignition	≤ 1.0 %
Heavy Metals	≤ 20 ppm
Biological Activity	Conforms to reference standard potency

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.