Description

Vancomycin is a potent glycopeptide antibiotic derived from *Amycolatopsis orientalis*, widely recognized for its critical role in combating severe Gram-positive bacterial infections. Its primary commercial value lies in its efficacy against methicillin-resistant *Staphylococcus aureus* (MRSA) and other multi-drug resistant pathogens, making it a last-line defense in clinical settings. This high-purity active pharmaceutical ingredient (API) is essential for manufacturers in the pharmaceutical industry producing injectable formulations, oral solutions, and other sterile medicinal products.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for systemic treatment of severe infections.
• Hospital-Acquired Infection Treatment: Critical for managing infections like septicemia, endocarditis, skin and bone infections caused by MRSA and other resistant bacteria.
• Oral Formulations: Used in the production of oral solutions for the treatment of *Clostridioides difficile*-associated colitis.
• Research & Development: Serves as a reference standard and key reagent in microbiological research, antibiotic resistance studies, and new drug development.
• Veterinary Medicine: Employed in certain veterinary applications for treating serious bacterial infections in animals.

Basic Information

Product Name	Vancomycin
CAS No.	1404-90-6
Molecular Formula	C66H75Cl2N9O24
Molecular Weight	1449.3 g/mol
Synonyms	Vancomycin Hydrochloride; Vancocin; Vancomycin A; LY107452; NSC 628054; (1S,2R,18R,19R,22S,25R,28R,40S)-48-{[(2S,3R,4S,5S,6R)-4-Amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-22-(carbamoylmethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanamido]methyl}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2³,⁶.2¹⁴,¹⁷.1⁸,¹².1²⁹,³³.0¹⁰,²⁵.0³⁴,³⁹]pentaconta-3,5,8,10,12(48),14,16,29(45),30,32,34,36,46,49-tetradecaene-40-carboxylic acid
EINECS	215-772-6

Quality Control

Our Vancomycin is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP, EP, and JP. Every batch undergoes rigorous analytical testing including HPLC for potency, specific tests for related substances and impurities, and comprehensive microbiological examination. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and adherence to specified purity and safety criteria.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	95.0% - 102.0% (on anhydrous basis)
pH (1% solution)	2.5 - 4.5
Water (Karl Fischer)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any individual impurity ≤ 2.0%
Bacterial Endotoxins	< 0.25 EU/mg
Sterility (if required)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.