Description

Gramicidin is a potent polypeptide antibiotic complex, primarily composed of gramicidin A, B, C, and D, known for its bactericidal activity against Gram-positive bacteria. Its unique mechanism of action, forming ion channels in bacterial cell membranes, makes it a critical component in topical pharmaceutical formulations and microbiological research. This product is essential for manufacturers in the pharmaceutical, biotechnology, and life science research sectors requiring a high-purity antimicrobial agent.

Application

• Topical Pharmaceutical Preparations: A key active ingredient in creams, ointments, and ophthalmic solutions for the prevention and treatment of bacterial infections.
• Microbiological Research: Used as a selective agent in culture media and in studies of ion channel formation and membrane biophysics.
• Combination Therapies: Often combined with other antibiotics like neomycin and polymyxin B for broad-spectrum antimicrobial efficacy.
• Veterinary Medicine: Employed in topical treatments for animal skin and eye infections.
• Biochemical Reagent: Serves as a standard or reagent in laboratory assays and quality control testing within the pharmaceutical industry.

Basic Information

Product Name	Gramicidin
CAS No.	1405-97-6
Molecular Formula	C99H140N20O17 (Gramicidin A)
Molecular Weight	~1882.3 g/mol (Gramicidin A)
Synonyms	Gramicidin D; Gramicidin from Bacillus brevis; Gramicidin A, B, C, D mixture; Gramicidin S (Note: Gramicidin S is a distinct cyclic variant); Tyrocidine (related peptide complex); Gramoderm; Antibiotic JI-20A; UNII-99X8A3A1SR
EINECS	215-786-5

Quality Control

Our Gramicidin is produced and tested under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and microbiological data. We can supply material compliant with relevant pharmacopoeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 95.0% (Total gramicidins)
Potency	≥ 900 µg/mg
Loss on Drying	≤ 5.0 %
Residue on Ignition	≤ 1.0 %
Microbial Limits	Meets Ph. Eur./USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.