Description

S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenethioate is a sophisticated, high-purity biochemical compound designed for advanced research and pharmaceutical development. This molecule is of significant interest due to its unique structure, which combines a modified adenosine nucleotide moiety with an arachidonoyl thioester, making it a valuable tool for studying cell signaling pathways, lipid metabolism, and enzyme kinetics. It is primarily sought after by researchers and developers in the fields of pharmaceutical R&D, biochemistry, and molecular biology for its potential in probing complex biological mechanisms.

Application

• Biochemical Research: As a key intermediate or reference standard in studies of nucleotide-lipid conjugates and their role in cellular signaling.
• Enzymology Studies: Used as a substrate or inhibitor to investigate the activity and specificity of phospholipases, kinases, and other lipid-modifying enzymes.
• Pharmaceutical Development: Serves as a critical building block or a pharmacological probe in the discovery of novel therapeutics targeting metabolic disorders, inflammation, or cancer pathways.
• Metabolic Pathway Analysis: Employed in tracer studies to elucidate the biosynthesis and catabolism of complex lipid mediators within cells.
• High-Throughput Screening (HTS): Utilized in assay development for drug discovery campaigns focused on lipid-related targets.
• Academic Research: A vital reagent for universities and research institutes exploring the intersection of nucleotide and fatty acid biochemistry.

Basic Information

Product Name	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenethioate
CAS No.	17046-56-9
Molecular Formula	C39H63N7O16P3S
Molecular Weight	1002.93 g/mol
Synonyms	Arachidonoyl Coenzyme A thioester analog; Modified Coenzyme A derivative; Nucleotide-Arachidonate conjugate; 5Z,8Z,11Z,14Z-Eicosatetraenoyl-CoA analog; Arachidonoyl-AMP derivative; Lipidated adenosine phosphate; Biochemical probe for lipid signaling; Research biochemical 17046-56-9
EINECS	Contact for details

Quality Control

Our production of this high-value biochemical adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analysis, including HPLC for purity verification and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support development under GMP-like conditions where required for pre-clinical research phases.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.