Description

S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-oct-2-enethioate is a sophisticated, high-purity biochemical intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of novel nucleotide-based therapeutics and prodrugs. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of targeted antiviral agents, oncology treatments, and other innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of nucleotide analogs and prodrugs targeting viral polymerases.
• Antiviral Drug Development: Research and production of novel therapeutic agents for hepatitis, influenza, and other viral infections.
• Oncology Research: Used in the development of chemotherapeutic agents that interfere with cancer cell DNA/RNA synthesis.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Prodrug Synthesis: Enables the creation of masked, bioactivatable forms of active pharmaceutical ingredients (APIs) to improve bioavailability and targeting.
• Pre-clinical & Clinical Trial Material: Supplied as a high-purity raw material for non-clinical studies and the manufacture of clinical trial batches.

Basic Information

Product Name	S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-oct-2-enethioate
CAS No.	10018-94-7
Molecular Formula	C₂₈H₄₈N₇O₁₆P₃S
Molecular Weight	887.70 g/mol
Synonyms	Adenosine triphosphate derivative; Nucleotide-lipid conjugate; (2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-[[hydroxy[[[[3-[[2-[[(2E)-1-oxooct-2-en-1-yl]thio]ethyl]amino]-3-oxopropyl]amino]carbonyl]-2-hydroxy-3,3-dimethylbutoxy]phosphinyl]oxy]phosphinyl]oxymethyl]oxolan-3-yl dihydrogen phosphate; Custom nucleotide prodrug intermediate; ATP-lipid hybrid molecule; Phosphorylated nucleoside analog.
EINECS	Contact for details

Quality Control

Our production of this advanced biochemical adheres to stringent quality systems suitable for GMP-grade intermediates. Every batch is characterized and released against a comprehensive specification, ensuring identity, purity, and potency for critical research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results from advanced analytical techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); containers must be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.