Description

Ondansetronhcl CAS NO 996140-01-4 is the hydrochloride salt form of Ondansetron, a potent and highly selective serotonin 5-HT3 receptor antagonist. This compound is critically important for its antiemetic properties, effectively preventing nausea and vomiting induced by chemotherapy, radiotherapy, and post-operative conditions. It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the production of injectable solutions, oral tablets, and orally disintegrating films.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiemetic drug formulations.
• Injectable Solutions: Manufacture of sterile intravenous (IV) and intramuscular (IM) injections for hospital and clinical use.
• Oral Solid Dosages: Production of standard tablets and orally disintegrating tablets (ODTs) for patient convenience.
• Oncology Supportive Care: Key component in medications to manage chemotherapy-induced nausea and vomiting (CINV).
• Post-Operative Care: Used in drugs to prevent and treat nausea and vomiting following surgical procedures.
• Radiotherapy Adjunct: Formulated into medications to control emesis caused by radiation therapy.
• Research & Development: Serves as a reference standard and building block in preclinical and clinical research for new antiemetic therapies.

Basic Information

Product Name	Ondansetronhcl
CAS No.	996140-01-4
Molecular Formula	C18H19N3O·HCl
Molecular Weight	329.82 g/mol (as hydrochloride)
Synonyms	Ondansetron Hydrochloride; Ondansetron HCl; 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride; GR 38032F; Zofran (brand name active ingredient); 5-HT3 Receptor Antagonist; Antiemetic API
EINECS	Contact for details

Quality Control

Our Ondansetron Hydrochloride is manufactured under strict quality systems. We ensure compliance with major pharmacopoeial standards, including USP and EP monographs, and can supply material suitable for GMP manufacturing. Each batch undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling. Certificates of Analysis (COA) documenting purity, identity, and all critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Chromatographic Purity	≥ 99.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.