Description

Domperidone is a potent and selective dopamine D2 and D3 receptor antagonist, widely recognized for its antiemetic and gastroprokinetic properties. Its primary commercial value lies in its critical role as an active pharmaceutical ingredient (API) for the formulation of safe and effective medications. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for nausea, vomiting, and gastrointestinal motility disorders.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for nausea and vomiting, particularly associated with chemotherapy, radiotherapy, and dopamine agonist therapy (e.g., for Parkinson's disease).
• Gastroprokinetic Agent: Formulated into drugs to treat symptoms of functional dyspepsia, gastroparesis, and gastroesophageal reflux disease (GERD) by enhancing gastric emptying and gastrointestinal motility.
• Veterinary Medicine: Used in veterinary pharmaceuticals to manage emesis and gastrointestinal stasis in companion animals.
• Biochemical Research: Serves as a critical reference standard and tool compound in pharmacological studies targeting dopamine receptors and gastrointestinal physiology.
• Drug Development: Utilized in the R&D of new dosage forms, including orally disintegrating tablets and other patient-friendly formulations.

Basic Information

Product Name	Domperidone
CAS No.	118435-03-3
Molecular Formula	C22H24ClN5O2
Molecular Weight	425.91 g/mol
Synonyms	5-Chloro-1-[1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one; Motilium; Domperidonum; Domperidona; Dompéridone; R 33812; ABT-259; EINECS 401-750-2
EINECS	401-750-2

Quality Control

Our Domperidone API is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP, EP, and JP. Every batch undergoes comprehensive analytical testing including identification, assay, impurity profiling (related substances), and residual solvent analysis. A Certificate of Analysis (COA) documenting full compliance with agreed specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF Titration)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.