Description

Ricasetron CAS NO 117086-68-7 is a selective serotonin 5-HT3 receptor antagonist. This compound is a critical intermediate in the synthesis of advanced pharmaceutical active ingredients (APIs), particularly those targeting nausea and vomiting. It is essential for manufacturers in the pharmaceutical and fine chemical industries requiring high-purity building blocks for neurological and oncological therapeutics. The material's specific stereochemistry and purity are paramount for ensuring the efficacy and safety of the final drug product.

Application

• Pharmaceutical Intermediate: Primary use as a key chiral building block in the synthesis of potent 5-HT3 receptor antagonist APIs.
• Research & Development: Utilized in medicinal chemistry for the development of new antiemetic and neurological drug candidates.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of finished dosage forms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.

Basic Information

Product Name	Ricasetron
CAS No.	117086-68-7
Molecular Formula	C17H20N2O2
Molecular Weight	284.36 g/mol
Synonyms	(3R)-3-[(1-Methyl-1H-indol-3-yl)methyl]-1-azabicyclo[2.2.2]octan-8-ol; Ricasetron; (R)-Ricasetron; UNII-1J484S8K8F; 1-Azabicyclo[2.2.2]octan-8-ol, 3-[(1-methyl-1H-indol-3-yl)methyl]-, (3R)-; (R)-3-[(1-Methylindol-3-yl)methyl]quinuclidin-8-ol
EINECS	Contact for details

Quality Control

Our Ricasetron is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.