Description

Dolasetron Mesylate is a potent and selective serotonin 5-HT3 receptor antagonist. This compound is critical for the prevention and treatment of chemotherapy-induced and postoperative nausea and vomiting (CINV and PONV). It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in developing and producing antiemetic formulations, offering a reliable solution for patient care in oncology and surgical settings.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of injectable and oral antiemetic medications.
• Chemotherapy-Induced Nausea and Vomiting (CINV) Prevention: Formulated for use in cancer patients undergoing emetogenic chemotherapy regimens.
• Postoperative Nausea and Vomiting (PONV) Management: Used in clinical settings to prevent nausea and vomiting following surgical procedures.
• Research and Development: Serves as a reference standard and key intermediate in pharmacological studies and new drug development targeting the 5-HT3 pathway.
• Generic Drug Production: Essential for companies producing bioequivalent versions of established antiemetic drugs.

Basic Information

Product Name	Dolasetron Mesylate
CAS No.	115956-13-3
Molecular Formula	C19H20N2O3 • CH4O3S
Molecular Weight	412.47 g/mol
Synonyms	Dolasetron Methanesulfonate; MDL 73,147EF; Anzemet (brand name); (2α,6α,8α,9αβ)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate monomethanesulfonate; BIMU 8; BIMU-8; BIMU8
EINECS	Contact for details

Quality Control

Our Dolasetron Mesylate is manufactured under strict quality systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.