Description

Granisetron Hydrochloride is a high-purity, selective serotonin 5-HT₃ receptor antagonist used to prevent nausea and vomiting. Its efficacy and reliability make it a critical active pharmaceutical ingredient (API) in modern therapeutic formulations. This compound is essential for manufacturers in the pharmaceutical industry developing injectable solutions, oral tablets, and other antiemetic medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiemetic drugs for chemotherapy-induced nausea and vomiting (CINV).
• Injectable Formulations: Manufacture of sterile solutions for intravenous or intramuscular administration in clinical settings.
• Oral Solid Dosage Forms: Production of tablets and capsules for postoperative nausea and vomiting (PONV) prevention.
• Oncology Supportive Care: A key component in medication regimens to improve patient quality of life during cancer treatment.
• Generic Drug Manufacturing: Sourcing for cost-effective production of bioequivalent generic antiemetics.
• Research & Development: Used in preclinical and clinical studies for developing new antiemetic therapies or combination drugs.

Basic Information

Product Name	Granisetron Hydrochloride
CAS No.	107007-99-8
Molecular Formula	C18H24N4O • HCl
Molecular Weight	348.87 g/mol (as hydrochloride salt)
Synonyms	Granisetron HCl; 1-Methyl-N-((3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H-indazole-3-carboxamide hydrochloride; BRL 43694A; Kytril (brand name equivalent); Sancuso (brand name equivalent); 5-HT3 antagonist; Antiemetic Agent
EINECS	Contact for details

Quality Control

Our Granisetron Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identification by IR and NMR, to ensure it meets pharmaceutical-grade standards. Certificates of Analysis (COA) documenting compliance with in-house specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.