Description

Tropisetron is a potent and selective serotonin 5-HT₃ receptor antagonist. This compound is critical for the prevention and treatment of chemotherapy-induced and postoperative nausea and vomiting (CINV and PONV). It is an essential active pharmaceutical ingredient (API) sought by pharmaceutical manufacturers and research institutions globally for developing effective antiemetic formulations.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable and oral antiemetic medications.
• Chemotherapy-Induced Nausea & Vomiting (CINV): Prevention and treatment of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
• Postoperative Nausea & Vomiting (PONV): Prophylaxis and management of nausea and vomiting following surgical procedures.
• Research & Development: Biochemical research targeting the 5-HT₃ receptor pathway and development of novel therapeutic agents.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Formulation Development: Serves as a key component in the development of generic and new drug formulations, including controlled-release systems.

Basic Information

Product Name	Tropisetron
CAS No.	89565-68-4
Molecular Formula	C₁₇H₂₀N₂O₂
Molecular Weight	284.36 g/mol
Synonyms	ICS 205-930; Navoban; (1αH,3α,5αH)-Tropan-3-yl 1H-indole-3-carboxylate; 1H-Indole-3-carboxylic acid (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Tropisetron Hydrochloride (salt form); Indisetron (related compound); 5-HT3 antagonist ICS 205-930
EINECS	Contact for details

Quality Control

Our Tropisetron is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, ensuring traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.