Description

Dolasetron CAS NO 115956-12-2 is a potent and selective serotonin 5-HT3 receptor antagonist. This compound is critical for the prevention and treatment of chemotherapy-induced and postoperative nausea and vomiting (CINV and PONV). It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers and research institutions developing and producing antiemetic medications.

Application

• Pharmaceutical API: Core active ingredient in the formulation of injectable and oral antiemetic drugs.
• Chemotherapy-Induced Nausea and Vomiting (CINV) Prevention: Used in medications administered to cancer patients undergoing emetogenic chemotherapy regimens.
• Postoperative Nausea and Vomiting (PONV) Management: Key component in drugs used to prevent nausea after surgical procedures.
• Research and Development: Reference standard and building block in pharmacological studies of 5-HT3 receptor antagonists and new therapeutic entities.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of established dolasetron-based antiemetics.
• Veterinary Medicine: Potential application in controlling emesis in animals undergoing treatments that trigger severe nausea.

Basic Information

Product Name	Dolasetron
CAS No.	115956-12-2
Molecular Formula	C19H20N2O3
Molecular Weight	324.38 g/mol
Synonyms	Dolasetron Mesylate (salt form); MDL 73,147EF; Anzemet (brand name); (2α,6α,8α,9αβ)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate; 2,6-Methano-2H-quinolizine-8-carboxylic acid, 1,3,4,6,7,11b-hexahydro-2,7-dioxo-9,10-dimethoxy-, methyl ester, (2α,6α,8α,9αβ)-; BIMU 8
EINECS	Contact for details

Quality Control

Our Dolasetron is manufactured under strict quality systems. It undergoes rigorous analytical testing to ensure high purity and compliance with relevant pharmacopeial standards (such as USP/EP monographs where applicable). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to guarantee supply reliability and consistent quality for your formulations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.