Description

Metoclopramide Hydrochloride is a potent dopamine receptor antagonist and serotonin receptor agonist, primarily used as an antiemetic and gastroprokinetic agent. Its value lies in its ability to effectively control nausea and vomiting while accelerating gastric emptying, making it a critical component in therapeutic formulations. This high-purity active pharmaceutical ingredient (API) is essential for manufacturers in the pharmaceutical industry developing injectable and oral dosage forms.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiemetic and gastroprokinetic drug formulations.
• Injectable Solutions: Used in the production of sterile injectables for rapid control of postoperative and chemotherapy-induced nausea.
• Oral Dosage Forms: Key component in tablets, capsules, and syrups for the treatment of gastroparesis and gastroesophageal reflux.
• Veterinary Medicine: Employed in veterinary pharmaceuticals to manage emesis and gastrointestinal motility disorders in animals.
• Research & Development: Serves as a reference standard and building block in pharmacological research and new drug development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for generic and proprietary drug production.

Basic Information

Product Name	Metoclopramide Hydrochloride
CAS No.	7232-21-5
Molecular Formula	C14H22ClN3O2 • HCl
Molecular Weight	336.26 g/mol
Synonyms	4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride; Metoclopramide HCl; Metoclopramide Monohydrochloride; Primperan; Reglan; Maxolon; Clopamon; Plasil; EINECS 230-625-5
EINECS	230-625-5

Quality Control

Our Metoclopramide Hydrochloride is manufactured under strict quality management systems. It is tested to meet or exceed relevant pharmacopoeial standards such as USP, EP, and BP. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure regulatory compliance and batch-to-batch consistency for our global pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (on dried basis)	98.5% - 101.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.