Description

Metopimazine is a high-purity phenothiazine derivative pharmaceutical intermediate with significant therapeutic relevance. This compound is valued for its specific pharmacological activity, primarily as a potent antiemetic agent used to prevent and treat nausea and vomiting. It is a critical building block for pharmaceutical manufacturers and research institutions developing advanced therapeutic formulations. Sourcing a reliable supply of Metopimazine CAS NO 14008-44-7 is essential for ensuring consistent quality in final drug products and research outcomes.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a key intermediate in the manufacture of antiemetic medications.
• Pharmaceutical Research & Development: Serves as a reference standard and starting material in preclinical and clinical studies for new anti-nausea therapies.
• Formulation Development: Used in the development of various dosage forms, including tablets, injectables, and suppositories.
• Chemical Synthesis: Acts as a versatile phenothiazine precursor for synthesizing novel chemical entities with potential biological activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of finished drug products.

Basic Information

Product Name	Metopimazine
CAS No.	14008-44-7
Molecular Formula	C₂₂H₂₉N₃O₂S
Molecular Weight	399.55 g/mol
Synonyms	Metopimazine; 1-[(8-Methyl-10H-phenothiazin-2-yl)carbonyl]-4-piperidinopiperidine; Vogalene; Vogalen; 14008-44-7; 1-[(8-Methyl-10H-phenothiazin-2-yl)carbonyl]-4-(piperidin-1-yl)piperidine; 1-(8-Methylphenothiazin-2-ylcarbonyl)-4-piperidinopiperidine
EINECS	Contact for details

Quality Control

Our Metopimazine is manufactured and tested under a strict quality management system to ensure it meets the high standards required for pharmaceutical applications. We provide comprehensive analytical data, including HPLC purity, identification by spectroscopic methods, and control of related substances and residual solvents. A Certificate of Analysis (COA) is provided with each batch, detailing compliance with agreed specifications. Our quality commitment supports regulatory filings and ensures supply chain reliability for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%; Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.