Description

Granisetron is a highly selective serotonin 5-HT₃ receptor antagonist, a critical active pharmaceutical ingredient (API) in the management of chemotherapy-induced and postoperative nausea and vomiting. Its efficacy and safety profile make it a cornerstone in supportive cancer care and surgical recovery protocols. This compound is essential for pharmaceutical manufacturers developing injectable solutions, oral tablets, and transdermal patches targeting oncology, anesthesiology, and gastroenterology sectors globally.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiemetic medications for preventing nausea and vomiting caused by cancer chemotherapy, radiotherapy, and surgery.
• Oncology Supportive Care: Formulated into injectable solutions (IV) for acute phase management and oral tablets for delayed phase control following highly emetogenic chemotherapy.
• Postoperative Care: Used in hospital settings to prevent and treat nausea and vomiting after surgical procedures.
• Transdermal Delivery Systems: Incorporated into patch formulations for sustained, controlled release over multiple days, improving patient compliance.
• Generic Drug Manufacturing: Sourced by generic pharmaceutical companies for producing bioequivalent versions of branded antiemetic drugs.
• Research & Development: Serves as a reference standard and key intermediate in pharmacological research and the development of new therapeutic formulations.

Basic Information

Product Name	Granisetron
CAS No.	109889-09-0
Molecular Formula	C18H24N4O
Molecular Weight	312.41 g/mol
Synonyms	BRL 43694; Kytril (brand name); Sancuso (brand name); 1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H-indazole-3-carboxamide; endo-1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H-indazole-3-carboxamide; Granisetron Hydrochloride (salt form); 5-HT3 Receptor Antagonist
EINECS	Contact for details

Quality Control

Our Granisetron is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards including USP, EP, and JP. Every batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting purity, related substances, and other critical parameters is provided with each shipment to ensure traceability and regulatory support for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.10% Total impurities: ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.