Description

1,23-Bis(Maleimido)Heptaethyleneglycol is a heterobifunctional crosslinking agent featuring a hydrophilic polyethylene glycol (PEG) spacer terminated with maleimide groups. This compound is engineered to facilitate the stable conjugation of biomolecules, such as proteins and peptides, under mild physiological conditions. It is a critical reagent for researchers and manufacturers in the fields of bioconjugation, advanced drug delivery systems, and the development of diagnostic assays.

Application

• Bioconjugation Reagent: For site-specific coupling of thiol-containing molecules (e.g., antibodies, peptides) to other functional groups like amines, enabling the creation of antibody-drug conjugates (ADCs) and other therapeutic bioconjugates.
• PEGylation Agent: Used to introduce a hydrophilic PEG spacer between two entities, improving solubility, stability, and pharmacokinetic profiles of therapeutic compounds.
• Hydrogel Formation: Acts as a crosslinker in the synthesis of biocompatible hydrogels for tissue engineering, 3D cell culture, and controlled release applications.
• Surface Functionalization: For modifying nanoparticles, biosensors, and chromatographic supports with reactive maleimide groups to immobilize biomolecules.
• Diagnostic Assay Development: Key component in constructing homogeneous immunoassays (e.g., FRET-based assays) by linking detection molecules.
• Protein/Enzyme Stabilization: Used to crosslink and stabilize protein structures, enhancing their thermal and operational stability.

Basic Information

Product Name	1,23-Bis(Maleimido)Heptaethyleneglycol
CAS No.	960257-46-9
Molecular Formula	C27H40N2O13
Molecular Weight	600.62 g/mol
Synonyms	BM(PEG)7; Bis-Maleimide-PEG7; 1,23-Bis(maleimido)-3,6,9,12,15,18,21-heptaoxatricosane; PEG7 bis-maleimide; Heptaethylene glycol bis-maleimide; α,ω-Bis-maleimido-poly(ethylene glycol); Maleimide-PEG7-Maleimide; Heterobifunctional PEG crosslinker, MW 600
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized to confirm identity, purity, and functional integrity. Certificates of Analysis (COA) detailing purity (by HPLC), functional group assay, and critical impurities are available upon request. We adhere to cGMP principles where applicable to support our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant (e.g., in a sealed bag with silica gel) to minimize hydrolysis of the maleimide groups and moisture absorption. For long-term storage, keep under an inert atmosphere (argon or nitrogen). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Functional)	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.