Description

α-Biotin-ω-Amino-Deca(Ethylene Glycol) is a specialized, high-purity heterobifunctional polyethylene glycol (PEG) derivative designed for advanced bioconjugation and linker chemistry. This compound is engineered to provide a robust and versatile platform for attaching biotinylated molecules to amino-functionalized surfaces, nanoparticles, or other biomolecules, enabling precise control in diagnostic and therapeutic applications. It is an essential reagent for researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and advanced materials science who require reliable, well-defined PEG spacers for surface modification, drug delivery systems, and assay development.

Application

• Bioconjugation Linker: Serves as a heterobifunctional crosslinker for attaching biotinylated probes, antibodies, or drugs to amino-functionalized carriers, surfaces, or other proteins.
• Diagnostic Assay Development: Used to functionalize sensor surfaces, microplates, or nanoparticles with biotin for streptavidin-based capture systems in ELISA, lateral flow assays, and biosensors.
• Drug Delivery & Targeting: Facilitates the creation of targeted therapeutic conjugates by linking biotinylated targeting ligands (e.g., antibodies, peptides) to amino-functionalized drug payloads or nanocarriers.
• Surface PEGylation: Employed to modify amino-coated surfaces (e.g., gold, silica, magnetic beads) with a dense, hydrophilic PEG layer terminated with biotin, reducing non-specific binding and enabling specific capture.
• Affinity Chromatography: Used in the synthesis of affinity resins by coupling the amino group to activated chromatography supports, creating a biotin-functionalized matrix for purifying streptavidin-fusion proteins.
• Biomaterial Functionalization: Key reagent for introducing biotin groups into hydrogels, scaffolds, or other biomaterials to control cell adhesion or incorporate bioactive signals.

Basic Information

Product Name	α-Biotin-ω-Amino-Deca(Ethylene Glycol)
CAS No.	960132-48-3
Molecular Formula	C34H64N4O13S
Molecular Weight	768.95 g/mol
Synonyms	Biotin-PEG10-Amine; Biotin-PEG10-NH2; Biotinylated PEG10 Amine; 5-[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide; Biotin-EG10-NH2; Amino-PEG10-Biotin; NH2-PEG10-Biotin; Biotin-Polyethylene Glycol-Amine (MW ~500)
EINECS	Contact for details

Quality Control

Every batch of α-Biotin-ω-Amino-Deca(Ethylene Glycol) is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and functional integrity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS analysis. Our quality protocols are designed to meet the stringent requirements of research and cGMP-grade material production for bioconjugation applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Functional Groups)	≥ 90% (by titration/NMR)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.