Description

Fmoc-Pna-U-Oh CAS NO 959151-70-3 is a specialized, high-purity Fmoc-protected amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled assembly of complex peptides and peptidomimetics, ensuring high coupling efficiency and minimal side reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, proteomics research, and the development of therapeutic peptides and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Enabling the creation of modified peptides with enhanced stability, bioavailability, or target specificity.
• Bioconjugation: Serving as a linker or functional handle for attaching peptides to other molecules, surfaces, or carriers.
• Combinatorial Chemistry Libraries: Used in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Industrial Research: Fundamental tool in biochemistry and molecular biology labs for studying protein-protein interactions and signal transduction pathways.

Basic Information

Product Name	Fmoc-Pna-U-Oh
CAS No.	959151-70-3
Molecular Formula	C₂₀H₂₀N₂O₅
Molecular Weight	368.38 g/mol
Synonyms	Fmoc-Pna-U-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)]-L-phenylalanine; Fmoc-L-4-(Uracil-1-yl)phenylalanine; Fmoc-4-(1-Uracyl)-L-phenylalanine; Fmoc-Phe(4-Ura)-OH; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-(2,4-dioxopyrimidin-1-yl)phenyl]propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Pna-U-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥95% (HPLC). Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.