Description

Sphingosine (D18:1) Alkyne is a high-purity, chemically modified derivative of the fundamental sphingolipid backbone, designed for advanced biochemical research and development. This alkyne-functionalized compound serves as a critical click chemistry reagent, enabling precise labeling and tracking of sphingolipid metabolism and localization in complex biological systems. It is an essential tool for researchers and developers in the fields of lipidomics, cell biology, and pharmaceutical discovery, particularly for those investigating sphingolipid-related signaling pathways, membrane dynamics, and drug-target interactions.

Application

• Click Chemistry Probes: Acts as a bioorthogonal handle for copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) to attach fluorescent dyes, biotin, or other tags for imaging and detection.
• Sphingolipid Metabolism Studies: Used to trace the synthesis, trafficking, and degradation of sphingolipids in live cells and model organisms via metabolic labeling techniques.
• Chemical Biology & Target Identification: Facilitates the discovery and validation of novel drug targets within the sphingolipid signaling network through activity-based protein profiling (ABPP).
• Lipidomics Research: Serves as a standard or internal standard for the mass spectrometric analysis and quantification of sphingoid bases and their derivatives.
• Membrane Biophysics: Incorporated into artificial membranes (liposomes, supported lipid bilayers) to study how specific lipid modifications influence membrane structure, fluidity, and protein interactions.
• Drug Delivery System Development: Utilized to functionalize lipid nanoparticles (LNPs) or liposomes for targeted delivery, enabling surface conjugation of targeting ligands or PEG chains.

Basic Information

Product Name	Sphingosine (D18:1) Alkyne
CAS No.	954096-91-4
Molecular Formula	C18H33NO2
Molecular Weight	295.46 g/mol
Synonyms	(2S,3R,4E)-2-Amino-4-octadecen-1,3-diol 1-Alkyne; D-erythro-Sphingosine Alkyne; trans-4-Sphingenine Alkyne; (E)-Sphing-4-enine Alkyne; 2-Amino-4-octadecene-1,3-diol Alkyne; Sphingosine Alkyne Derivative; Clickable Sphingosine; Alkyne-functionalized Sphingosine
EINECS	Contact for details

Quality Control

Our Sphingosine (D18:1) Alkyne is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, NMR, and MS, to confirm identity, purity, and the integrity of the alkyne functional group. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.