Description

2-Methoxyestrone-D4 is a stable isotope-labeled analog of the endogenous estrogen metabolite 2-methoxyestrone. This deuterated compound is an essential tool for quantitative bioanalytical research, providing unmatched accuracy and reliability in mass spectrometry-based assays. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions specializing in endocrinology and steroid metabolism studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of 2-methoxyestrone and related metabolites in complex biological matrices like plasma, serum, and urine.
• Metabolite Tracing & Pharmacokinetics: Enables detailed studies on the absorption, distribution, metabolism, and excretion (ADME) of estrogenic compounds in preclinical and clinical research.
• Biomarker Assay Development: Used in the development and validation of high-sensitivity diagnostic assays for hormonal balance and endocrine-related pathologies.
• Stable Isotope Dilution Analysis (SIDA): Provides the foundation for SIDA methodologies, ensuring high accuracy by correcting for analyte loss during sample preparation and instrument variability.
• Endocrinology Research: Facilitates advanced research into estrogen metabolism pathways, their role in health, and their implications in diseases such as cancer and osteoporosis.
• Quality Control Reference Material: Acts as a certified reference material for calibrating analytical instruments and verifying method performance in regulated laboratories.

Basic Information

Product Name	2-Methoxyestrone-D4
CAS No.	949885-90-9
Molecular Formula	C19H22D4O3
Molecular Weight	302.42 g/mol
Synonyms	2-Methoxyestra-1,3,5(10)-trien-3-ol-17-one-D4; 2-Methoxy-17-oxoestra-1,3,5(10)-trien-3-ol-D4; 2-Methoxy-1,3,5(10)-estratrien-3-ol-17-one-D4; Deuterated 2-Methoxyestrone; [2,4,16,16-D4]-2-Methoxyestrone; 2-MeOE1-D4; 2-Methoxy-E1-D4
EINECS	Contact for details

Quality Control

Every batch of 2-Methoxyestrone-D4 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity as verified by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, isotopic enrichment, and absence of critical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.