Description

Cortisol 21-Sulfate is a key sulfated metabolite of the endogenous glucocorticoid hormone cortisol. This compound is of significant value as a stable, water-soluble biomarker for clinical and research applications, offering insights into adrenal function and steroid metabolism pathways. It is primarily utilized by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions conducting endocrinology and metabolomics studies. The product is supplied to meet the stringent purity requirements of analytical and biological research.

Application

• Biomarker Standard for Clinical Diagnostics: Used as a certified reference material (CRM) in LC-MS/MS and ELISA kits for the quantitative analysis of cortisol sulfate in human serum, plasma, and urine.
• Pharmaceutical Research & Development: Serves as a critical intermediate or reference compound in the study of steroid metabolism, drug interactions, and the development of novel therapeutic agents targeting the HPA axis.
• Endocrinology and Metabolomics Studies: Employed in academic and institutional research to investigate disorders of adrenal function, stress response, and metabolic syndrome.
• Quality Control in Manufacturing: Acts as a system suitability standard and an impurity reference in the quality control of pharmaceutical-grade cortisol and related steroid APIs.
• Toxicology and Doping Control: Used in forensic and sports anti-doping laboratories to profile steroid profiles and detect the abuse of synthetic glucocorticoids.

Basic Information

Product Name	Cortisol 21-Sulfate
CAS No.	1253-43-6
Molecular Formula	C21H30O8S
Molecular Weight	442.52 g/mol
Synonyms	Hydrocortisone 21-Sulfate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-(Hydrogen Sulfate); Cortisol Sulfate; Cortisol 21-Hydrogen Sulfate; Reichstein's Substance M 21-Sulfate; (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(Hydrogen Sulfate)
EINECS	Contact for details

Quality Control

Every batch of Cortisol 21-Sulfate is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure identity, purity, and consistency, aligning with the expectations of research and pharmaceutical industries. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results from HPLC, NMR, and MS. Our quality systems support compliance with relevant standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.