Description

Sulfamethoxazole -D-Glucuronide is a key metabolite and analytical reference standard of the widely used antibiotic sulfamethoxazole. This high-purity compound is essential for pharmaceutical research, development, and quality control processes, enabling precise pharmacokinetic and metabolic studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical manufacturers involved in bioanalysis, method validation, and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative and qualitative analysis of sulfamethoxazole and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Critical for in vitro and in vivo studies to understand the metabolic pathways, clearance mechanisms, and bioavailability of sulfamethoxazole.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, and LC-MS/MS methods for therapeutic drug monitoring and toxicology studies.
• Regulatory Compliance & Documentation: Supports regulatory filings (e.g., FDA, EMA) by providing definitive proof of metabolite identity and purity in stability and impurity profiling studies.
• Clinical Research: Employed in clinical trials to accurately measure drug and metabolite concentrations in plasma, serum, and urine samples.
• Quality Control (QC) Testing: Acts as a system suitability standard and an impurity marker in the quality control of bulk sulfamethoxazole API and finished dosage forms.

Basic Information

Product Name	Sulfamethoxazole -D-Glucuronide
CAS No.	14365-52-7
Molecular Formula	C17H21N3O9S
Molecular Weight	443.43 g/mol
Synonyms	SMZ-D-Glucuronide; Sulfamethoxazole D-Glucuronide; Sulfamethoxazole Glucuronide; N1-(5-Methyl-3-isoxazolyl)sulfanilamide D-Glucuronide; 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide D-Glucuronide; Sulfamethoxazole β-D-Glucuronide; SMZ-Gluc; Sulfamethoxazole Metabolite
EINECS	Contact for details

Quality Control

Our Sulfamethoxazole -D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) detailing all test results, ensuring compliance with the stringent requirements for pharmaceutical reference standards. Our quality commitment supports your needs for reliable, traceable, and consistent materials in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.