Description

D-Thyroxine Monosodium Salt is the monosodium salt form of the dextrorotatory isomer of the thyroid hormone thyroxine. This compound is a critical chiral intermediate and reference standard in pharmaceutical research and development, particularly for metabolic and endocrine studies. It is essential for manufacturers and research institutions focused on developing and analyzing thyroid hormone analogs, diagnostic reagents, and biochemical tools.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of specialized thyroid hormone analogs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard in metabolic studies, receptor binding assays, and investigations into thyroid hormone action and cholesterol metabolism.
• Diagnostic Reagent Manufacturing: Employed in the production of calibration standards and components for in-vitro diagnostic (IVD) kits targeting thyroid function.
• Analytical Chemistry: Acts as a high-purity standard for method development and quality control in HPLC, LC-MS, and other analytical techniques.
• Veterinary Medicine: Potential use in research for developing metabolic treatments in animal health.

Basic Information

Product Name	D-Thyroxine Monosodium Salt
CAS No.	137-53-1
Molecular Formula	C15H10I4NNaO4
Molecular Weight	798.94 g/mol
Synonyms	Dextrothyroxine Sodium; Sodium D-Thyroxine; (R)-Thyroxine Sodium Salt; D-T4 Sodium Salt; Dextrothyroxine Sodium Salt; 3,3',5,5'-Tetraiodo-D-thyronine Sodium Salt; D-Thyroxine Na; UNII-2Y983G5D9N
EINECS	205-300-4

Quality Control

Our D-Thyroxine Monosodium Salt is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral identity, to ensure it meets exacting standards for research and manufacturing use. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.