Description

16A-Hydroxyestrone 16-B-D-Glucuronide is a specific, high-purity metabolite of estrone, formed via hydroxylation and subsequent glucuronidation. This compound is of significant value as a critical reference standard and analytical reagent in biochemical and clinical research. It is primarily needed by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions conducting studies on estrogen metabolism, hormone-related diseases, and biomarker discovery.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative calibration of analytical instruments (HPLC, LC-MS/MS) in drug metabolism and pharmacokinetic (DMPK) studies.
• Clinical Research & Diagnostics: Serves as a key calibrant for developing and validating diagnostic assays measuring estrogen metabolites in biological samples (serum, urine).
• Biomarker Investigation: Essential for research into hormone-dependent conditions, such as certain cancers, by studying metabolic pathways and exposure levels.
• Enzyme Activity Studies: Utilized as a substrate or product in assays to study the activity of enzymes like UDP-glucuronosyltransferases (UGTs).
• Toxicology & Safety Assessment: Employed in studies assessing the metabolic fate and excretion profiles of estrogenic compounds.
• Academic Research: A vital tool for universities and research institutes exploring endocrinology, steroid biochemistry, and metabolic disorders.

Basic Information

Product Name	16A-Hydroxyestrone 16-B-D-Glucuronide
CAS No.	15270-34-5
Molecular Formula	C24H32O9
Molecular Weight	464.51 g/mol
Synonyms	16α-Hydroxyestrone 16-Glucuronide; 16α-Hydroxyestrone 16-β-D-Glucopyranosiduronic Acid; Estrone, 16α-hydroxy-, 16-β-D-glucuronide; 16α-Hydroxyestrone 16-Glucuronoside; 16α-Hydroxyestrone 16-β-D-Glucuronide; 16α-OHE1-16G; 16α-Hydroxyestrone 16-β-Glucuronide
EINECS	Contact for details

Quality Control

Our 16A-Hydroxyestrone 16-B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.