Description

Dl-Normetanephrine Sulfate is a stable salt form of the endogenous catecholamine metabolite, normetanephrine. This compound is of significant value as a key biochemical reference standard and analytical reagent in clinical and pharmaceutical research. It is primarily required by diagnostic laboratories, pharmaceutical R&D departments, and academic institutions for use in method development, quality control, and quantitative analysis.

Application

• Clinical Diagnostics: Used as a primary reference standard for the accurate quantification of normetanephrine and metanephrines in patient samples (plasma, urine) via HPLC or LC-MS/MS, aiding in the diagnosis of pheochromocytoma and paraganglioma.
• Pharmaceutical Research: Serves as a critical metabolite standard in drug metabolism and pharmacokinetic (DMPK) studies for drugs affecting the adrenergic system.
• Biochemical Assay Development: Employed in the calibration and validation of immunoassays and enzymatic assays designed to detect catecholamine metabolites.
• Quality Control (QC) in Manufacturing: Acts as a system suitability standard and an impurity marker in the QC testing of pharmaceutical products related to neurological and cardiovascular functions.
• Academic & Life Science Research: Utilized in studies investigating catecholamine metabolism, sympathetic nervous system activity, and related physiological or pathological pathways.

Basic Information

Product Name	Dl-Normetanephrine Sulfate
CAS No.	1215-29-8
Molecular Formula	C9H13NO3 · H2SO4
Molecular Weight	291.28 g/mol
Synonyms	DL-Normetanephrine Hemisulfate Salt; (±)-Normetanephrine Sulfate; 3-Methoxy-4-hydroxyphenylethanolamine Sulfate; 4-Hydroxy-3-methoxyphenylethanolamine Sulfate; DL-3-O-Methyladrenaline Sulfate; DL-Metanephrine Sulfate (common misnomer); (±)-3-Methoxyepinephrine Sulfate
EINECS	Contact for details

Quality Control

Our Dl-Normetanephrine Sulfate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and spectroscopy, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, results, and test methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.