Description

n-Hydroxy-Succinimidy-Propionate Octa(Ethylene Glycol)-Disulfide is a heterobifunctional, water-soluble crosslinking reagent featuring an amine-reactive NHS ester and a cleavable disulfide bond. This compound matters for its ability to create reversible, reducible linkages in bioconjugation, enabling the development of stimuli-responsive drug delivery systems and analytical probes. It is primarily needed by researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and advanced material science for site-specific protein modification and controlled assembly.

Application

• Bioconjugation and Protein Labeling: For attaching fluorescent dyes, drugs, or other payloads to antibodies, peptides, and proteins via primary amines, with the disulfide bond allowing for controlled release under reducing conditions.
• Antibody-Drug Conjugate (ADC) Linker Development: Serves as a cleavable linker candidate for constructing ADCs, where the disulfide bond is cleaved in the reductive environment of the target cell.
• Surface Functionalization: Used to modify gold nanoparticles, biosensor chips, or other surfaces with biomolecules for diagnostic assays and sensing platforms.
• Polymer Chemistry: Acts as a crosslinker for synthesizing smart hydrogels or polymeric carriers that degrade in response to glutathione or other reducing agents.
• Proteomics Research: Employed in crosslinking mass spectrometry (XL-MS) to study protein-protein interactions and structural dynamics.
• Controlled Drug Delivery Systems: A key component in designing nanocarriers that release their therapeutic cargo specifically in tumor microenvironments characterized by higher reducing potential.

Basic Information

Product Name	n-Hydroxy-Succinimidy-Propionate Octa(Ethylene Glycol)-Disulfide
CAS No.	947601-98-1
Molecular Formula	C31H52N2O17S2
Molecular Weight	788.9 g/mol
Synonyms	NHS-PEG8-SS-PEG8-NHS; S-S-PEG8-NHS Ester; Disulfide-bis-PEG8-NHS; Bis(N-hydroxysuccinimide) ester of PEG8-disulfide; α-[3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-ω-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]octa(ethylene glycol) disulfide; Heterobifunctional PEG crosslinker, NHS-SS-PEG; 8-Arm PEG NHS Ester Disulfide (Note: This is a common but incorrect alias for the linear version)
EINECS	Contact for details

Quality Control

Our n-Hydroxy-Succinimidy-Propionate Octa(Ethylene Glycol)-Disulfide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store the product in a desiccator at -20°C or below for long-term stability. Under these conditions, the product is typically stable for 24 months. Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (NMR/HPLC)	≥ 90%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines
Functional Group Substitution	> 85%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.