Description

15-{[(1S)-1-Carboxy-4-[(2,5-Dioxopyrrolidin-1-Yl)Oxy]-4-Oxobutyl]Carbamoyl}Pentadecanoic Acid is a specialized bifunctional linker molecule featuring a carboxylic acid and an activated NHS ester group. This compound is critical for facilitating stable amide bond formation in aqueous and organic media, enabling the precise conjugation of biomolecules, polymers, and surfaces. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, proteomics, and advanced materials science for creating custom cross-linked structures and functionalized platforms.

Application

• Bioconjugation Reagent: For the covalent coupling of peptides, proteins, or antibodies to other molecules, surfaces, or nanoparticles via amine-reactive chemistry.
• Proteomics Research: As a cross-linker in mass spectrometry-based studies for analyzing protein-protein interactions and structural biology.
• Polymer Functionalization: To introduce reactive handles or specific functional groups into polymer chains for creating smart materials or drug delivery systems.
• Surface Immobilization: For the modification and activation of carboxylated surfaces (e.g., chips, beads) to enable the attachment of biomolecular probes.
• Diagnostic Assay Development: In the synthesis of labeled antigens, haptens, or detection reagents for immunoassays and biosensors.
• Chemical Biology Tool: For synthesizing activity-based probes or affinity tags to study enzyme function and cellular pathways.

Basic Information

Product Name	15-{[(1S)-1-Carboxy-4-[(2,5-Dioxopyrrolidin-1-Yl)Oxy]-4-Oxobutyl]Carbamoyl}Pentadecanoic Acid
CAS No.	943586-12-7
Molecular Formula	C25H38N2O9
Molecular Weight	510.58 g/mol
Synonyms	15-[(1S)-1-Carboxy-4-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-4-oxobutyl]carbamoyl]pentadecanoic Acid; (S)-4-((2,5-Dioxopyrrolidin-1-yl)oxy)-4-oxo-2-((15-oxo-15-(pentadecanoyloxy)pentadecanoyl)amino)butanoic Acid; NHS-Activated Long-Chain Dicarboxylic Acid; N-Succinimidyl Ester of α,ω-Dicarboxylic Acid; Heterobifunctional Crosslinker; CAS 943586-12-7
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity, identity, and impurity profiles. We adhere to Good Manufacturing Practice (GMP) principles for high-grade materials, ensuring batch-to-batch consistency and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and the activated ester moiety is susceptible to hydrolysis. For long-term stability, store under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.