Description

(S)-2-Amino-4-((((2R,3S,4R,5R)-5-(6-Amino-9H-Purin-9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl)(2-Iodoethyl)Amino)Butanoic Acid Dihydrochloride is a sophisticated nucleoside amino acid conjugate, representing a key building block in advanced pharmaceutical and biochemical research. Its value lies in its unique structure, which combines a modified adenosine moiety with an amino acid side chain, enabling precise molecular targeting and modification. This compound is essential for researchers and developers in medicinal chemistry, particularly for the synthesis of novel nucleotide-based therapeutics, prodrugs, and biochemical probes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, polymerases, and other nucleotide-binding proteins.
• Prodrug Development: Serves as a precursor for targeted prodrug strategies, leveraging its amino acid component for enhanced cellular uptake.
• Antisense Oligonucleotide (ASO) Synthesis: Potential modified monomer for the construction of advanced antisense or siRNA therapeutics with improved stability and specificity.
• Molecular Probe Synthesis: Used to create labeled probes for studying nucleic acid metabolism and intracellular trafficking.
• Medicinal Chemistry & SAR Studies: A key compound for structure-activity relationship (SAR) studies to optimize the efficacy and pharmacokinetic properties of nucleotide-derived drugs.

Basic Information

Product Name	(S)-2-Amino-4-((((2R,3S,4R,5R)-5-(6-Amino-9H-Purin-9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl)(2-Iodoethyl)Amino)Butanoic Acid Dihydrochloride
CAS No.	943440-14-0
Molecular Formula	C17H27Cl2IN8O6
Molecular Weight	637.26 g/mol
Synonyms	N6-Amino-2'-deoxyadenosine Amino Acid Conjugate Dihydrochloride; 2'-Deoxy-N6-(2-aminoethyl)adenosine Derivative Dihydrochloride; (S)-2-Amino-4-((2-iodoethyl)((2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)amino)butanoic Acid Dihydrochloride; 9-[(2R,3S,4R,5R)-5-[[(2S)-2-Amino-4-[(2-iodoethyl)amino]butanoyl]oxymethyl]-3,4-dihydroxytetrahydrofuran-2-yl]-9H-purin-6-amine Dihydrochloride; Modified Nucleoside-Amino Acid Hybrid; Iodoethylamino Nucleoside Conjugate
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-4-((((2R,3S,4R,5R)-5-(6-Amino-9H-Purin-9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl)(2-Iodoethyl)Amino)Butanoic Acid Dihydrochloride is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.