Description

Dpeg(R)4-Sata (S-Acetyl-Dpeg(R)4-Nhs Ester) is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an amine-reactive NHS ester and a thiol-reactive SATA group, separated by a tetraethylene glycol spacer. This compound is engineered for the controlled, site-specific conjugation of biomolecules, enabling the creation of stable, well-defined bioconjugates for advanced research and development. It is a critical reagent for scientists and process developers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, peptide/protein modification, and diagnostic assay manufacturing.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the controlled attachment of cytotoxic payloads to monoclonal antibodies via lysine residues.
• Protein and Peptide Labeling: Site-specific introduction of fluorophores, biotin, or other probes for imaging and detection.
• PEGylation Reagent: To impart improved solubility, stability, and reduced immunogenicity to therapeutic proteins and peptides.
• Surface Functionalization: Modification of nanoparticles, biosensors, or microarray surfaces for specific biomolecule immobilization.
• Diagnostic Reagent Synthesis: Construction of enzyme-antibody conjugates or other detection complexes used in immunoassays.
• Crosslinking for Structural Studies: Mapping protein-protein interactions or stabilizing protein complexes for analysis.

Basic Information

Product Name	Dpeg(R)4-Sata (S-Acetyl-Dpeg(R)4-Nhs Ester)
CAS No.	937025-17-7
Molecular Formula	C24H40N2O12S
Molecular Weight	580.65 g/mol
Synonyms	S-Acetylthio-tetraethyleneglycol NHS ester; SATA-PEG4-NHS ester; NHS-PEG4-SATA; 2,5-Dioxopyrrolidin-1-yl 3-((2-(2-(2-(2-((3-acetylthio)propanamido)ethoxy)ethoxy)ethoxy)ethyl)carbamoyl)propanoate; N-(2-(2-(2-(2-((3-Acetylthio)propanamido)ethoxy)ethoxy)ethoxy)ethyl)-3-((2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropanamide; Heterobifunctional PEG crosslinker, NHS-PEG4-SATA; Acetylthio-PEG4-NHS
EINECS	Contact for details

Quality Control

Our Dpeg(R)4-Sata is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance in sensitive bioconjugation applications. Each lot is characterized by NMR, HPLC, and mass spectrometry to confirm identity, purity, and functional integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment, supporting compliance with GMP and ISO 9001 standards for research and process development use.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or oily solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.