Description

m-Peg12-Ots is a high-purity, monodisperse polyethylene glycol (PEG) derivative featuring a methoxy (m) group at one terminus and a tosylate (Ots) leaving group at the other. This bifunctional linker is engineered to facilitate controlled conjugation and polymer modification in advanced chemical synthesis. It is essential for researchers and manufacturers in the pharmaceutical and bioconjugation sectors who require precise, reproducible PEGylation to enhance the solubility, stability, and pharmacokinetic profiles of active compounds. The product is supplied under stringent quality control to ensure batch-to-batch consistency for critical applications.

Application

• Pharmaceutical PEGylation: A key reagent for attaching polyethylene glycol chains to therapeutic proteins, peptides, and small molecule drugs to improve bioavailability and reduce immunogenicity.
• Bioconjugation & Linker Chemistry: Serves as a heterobifunctional crosslinker for coupling biomolecules (e.g., antibodies, enzymes) to surfaces, particles, or other functional molecules.
• Polymer & Material Science: Used as a macro-initiator or functional monomer in the synthesis of block copolymers, hydrogels, and functionalized nanomaterials.
• Diagnostic Reagent Synthesis: Employed in the development of contrast agents, fluorescent probes, and assay components where water solubility and biocompatibility are critical.
• Prodrug Development: Facilitates the creation of cleavable PEG-drug conjugates for controlled release and targeted delivery systems.

Basic Information

Product Name	m-Peg12-Ots
CAS No.	936499-78-4
Molecular Formula	C31H64O15S
Molecular Weight	708.9 g/mol
Synonyms	mPEG12-OTs; Methoxy-PEG12-tosylate; 2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaheptatetracontan-37-yl 4-methylbenzenesulfonate; Monomethoxy Polyethylene Glycol 12 Tosylate; α-Methoxy-ω-tosyl-poly(ethylene glycol) (n~12); PEG12 Methyl Ether Tosylate; mPEG12-OTs; O-(Methoxydodecaethylene glycol) p-toluenesulfonate
EINECS	Contact for details

Quality Control

Our m-Peg12-Ots is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurity profiles. We are committed to providing materials that support regulatory filings and ensure reproducibility in your sensitive conjugation workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
PEG Chain Length (n)	~12 (by NMR)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.