Description

(+)-D-Pyroglutamol p-Toluenesulfonate is a high-purity chiral intermediate and building block, specifically the tosylate salt of D-pyroglutaminol. This compound matters for its role in the stereoselective synthesis of complex molecules, offering critical control over the three-dimensional structure of the final product. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of peptidomimetics, proline analogs, and other bioactive compounds where the D-configuration is essential for activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders.
• Peptidomimetic Synthesis: Used to introduce constrained proline-like structures into peptide backbones to enhance stability, bioavailability, and receptor selectivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands and organocatalysts used in enantioselective transformations.
• Biochemical Research: Employed in studies of enzyme inhibition, receptor binding, and as a standard for analytical method development in chiral separations.
• Fine Chemical Production: Utilized in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	(+)-D-Pyroglutamol p-Toluenesulfonate
CAS No.	128899-31-0
Molecular Formula	C12H15NO4S
Molecular Weight	269.32 g/mol
Synonyms	(2R)-2-(Hydroxymethyl)-5-oxopyrrolidine-1-carboxylic acid 4-methylbenzenesulfonate; D-Pyroglutaminol p-toluenesulfonate; (R)-2-(Hydroxymethyl)-5-oxopyrrolidinium p-toluenesulfonate; (R)-Pyroglutaminol tosylate; (R)-5-Oxo-2-pyrrolidinemethanol p-toluenesulfonate; D-2-Pyrrolidinemethanol, 5-oxo-, p-toluenesulfonate; Tosylate salt of D-pyroglutaminol
EINECS	Contact for details

Quality Control

Our (+)-D-Pyroglutamol p-Toluenesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess (ee), and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.