Description

Sgi-110 is a potent and selective small molecule inhibitor of DNA methyltransferase 1 (DNMT1), a key epigenetic regulator. This compound is crucial for research and development in oncology and epigenetics, offering a targeted approach to modulate gene expression. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer therapeutics and epigenetic drug discovery.

Application

• Epigenetic Research Tool: Used as a reference standard and active compound in studies investigating DNA methylation mechanisms and their role in gene silencing.
• Oncology Drug Discovery: Serves as a lead compound or pharmacologic agent in preclinical research for developing novel cancer therapies targeting hypomethylating activity.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro enzymatic assays to evaluate DNMT1 inhibition and potency.
• Cell Culture Studies: Applied in cellular models to study the effects of DNA demethylation on cell proliferation, differentiation, and apoptosis.
• Combination Therapy Studies: Investigated in research settings for potential synergistic effects with other anticancer agents, such as histone deacetylase (HDAC) inhibitors.

Basic Information

Product Name	Sgi-110
CAS No.	929901-49-5
Molecular Formula	C12H19N5O4
Molecular Weight	297.31 g/mol
Synonyms	Guadecitabine; S-110; SGI 110; 2'-Deoxy-5-azacytidine dimer; NPEOC-DAC dimer; 5-Aza-2'-deoxycytidine dimer; DNMT1 Inhibitor SGI-110; Guadecitabine sodium (salt form)
EINECS	Contact for details

Quality Control

Our Sgi-110 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure compliance with research-grade standards and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.