Description

Ac-Leu-Arg-Amc is a fluorogenic peptide substrate designed for the detection and quantification of protease activity. This compound is critical for biochemical research and pharmaceutical development, enabling precise measurement of enzyme kinetics and inhibitor screening. It is primarily utilized by researchers and quality control laboratories in the life sciences, biotechnology, and pharmaceutical industries.

Application

• Protease Activity Assays: Used as a selective substrate for monitoring the enzymatic activity of specific proteases, such as trypsin-like enzymes.
• High-Throughput Screening (HTS): Employed in drug discovery platforms to identify and characterize novel protease inhibitors.
• Biochemical Research: Facilitates the study of protease function, kinetics, and regulation in various biological pathways.
• Diagnostic Development: Serves as a key component in developing fluorometric diagnostic kits for disease biomarkers related to protease activity.
• Quality Control in Biologics: Applied in purity and potency testing of therapeutic enzymes and related biopharmaceutical products.

Basic Information

Product Name	Ac-Leu-Arg-Amc
CAS No.	929621-79-4
Molecular Formula	C24H40N8O6
Molecular Weight	536.63 g/mol
Synonyms	Acetyl-Leucyl-Arginyl-7-Amino-4-Methylcoumarin; N-Acetyl-L-leucyl-L-arginine-7-amido-4-methylcoumarin; Ac-Leu-Arg-AMC; Ac-Leu-Arg-AMC trifluoroacetate salt; Ac-L-R-AMC; Protease Substrate Ac-Leu-Arg-AMC; Fluorogenic Peptide Substrate Ac-Leu-Arg-AMC; L-Leucine, N-acetyl-, L-argininamide deriv.
EINECS	Contact for details

Quality Control

Our Ac-Leu-Arg-Amc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.