Description

Diflorasone 17-Propionate is a synthetic corticosteroid ester, a potent anti-inflammatory agent derived from diflorasone. This compound is valued for its high glucocorticoid receptor affinity, making it a critical intermediate in the development of topical pharmaceutical formulations. It is primarily utilized by pharmaceutical R&D departments and manufacturers specializing in dermatological treatments for conditions such as psoriasis, eczema, and dermatitis.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the manufacture of high-potency topical corticosteroid APIs.
• Dermatological Creams and Ointments: Used in the formulation of prescription-strength topical medications for treating inflammatory skin disorders.
• Veterinary Pharmaceuticals: Incorporated into topical preparations for managing skin inflammation and allergic reactions in animals.
• Pharmaceutical Research & Development: Serves as a reference standard and a building block in the discovery and development of new steroidal anti-inflammatory drugs.
• Analytical Standard: Employed as a certified reference material (CRM) in quality control laboratories for HPLC, LC-MS, and other analytical methods.

Basic Information

Product Name	Diflorasone 17-Propionate
CAS No.	924726-89-6
Molecular Formula	C26H32F2O6
Molecular Weight	478.53 g/mol
Synonyms	Diflorasone Propionate; 6α,9α-Difluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate; 17-Propionyloxy-6α,9α-difluoro-11β,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione; 6α,9α-Difluoro-11β,21-dihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 17-propionate; Diflorasone 17-propanoate
EINECS	Contact for details

Quality Control

Our Diflorasone 17-Propionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure compliance with ICH guidelines and customer-specific requirements. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.