Description

Ethyl 1-{[5-(2,5-Dioxopyrrolidin-1-Yl)-2-Methoxyphenyl]Sulfonyl}Piperidine-3-Carboxylate is a high-purity, specialized chemical building block featuring a reactive N-hydroxysuccinimide (NHS) ester group. This compound is critical for facilitating efficient and stable bioconjugation reactions, enabling the formation of amide bonds under mild aqueous conditions. It is primarily utilized by researchers and process chemists in the pharmaceutical and biotech industries for the development of novel therapeutics, diagnostic agents, and advanced biomaterials.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs) and antibody-drug conjugates (ADCs) for targeted cancer therapies.
• Bioconjugation & Protein Labeling: Used to covalently attach peptides, proteins, antibodies, or other biomolecules to drugs, fluorophores, or solid supports via amine groups.
• Proteomics Research: Employed in the preparation of affinity probes, enzyme substrates, and other tools for studying protein function and interaction networks.
• Diagnostic Reagent Synthesis: Serves as a linker molecule in the production of immunoassay components, biosensors, and in-vitro diagnostic (IVD) kits.
• Polymer & Material Science: Functionalizes polymers, nanoparticles, and surfaces with bioactive ligands for drug delivery systems and tissue engineering scaffolds.
• Chemical Biology Tool Development: Integral for creating cross-linking agents, activity-based probes, and other chemical tools to interrogate biological systems.

Basic Information

Product Name	Ethyl 1-{[5-(2,5-Dioxopyrrolidin-1-Yl)-2-Methoxyphenyl]Sulfonyl}Piperidine-3-Carboxylate
CAS No.	919625-32-4
Molecular Formula	C20H24N2O8S
Molecular Weight	452.48 g/mol
Synonyms	Ethyl 1-((5-(2,5-dioxopyrrolidin-1-yl)-2-methoxyphenyl)sulfonyl)piperidine-3-carboxylate; 1-{[5-(2,5-Dioxo-1-pyrrolidinyl)-2-methoxyphenyl]sulfonyl}-3-piperidinecarboxylic Acid Ethyl Ester; 3-Piperidinecarboxylic acid, 1-[[5-(2,5-dioxo-1-pyrrolidinyl)-2-methoxyphenyl]sulfonyl]-, ethyl ester; NHS-Activated Sulfonyl Piperidine Ester; Sulfonyl NHS Ester Piperidine Derivative
EINECS	Contact for details

Quality Control

Our Ethyl 1-{[5-(2,5-Dioxopyrrolidin-1-Yl)-2-Methoxyphenyl]Sulfonyl}Piperidine-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic and light-sensitive nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to maintain stability and prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.