Description

(S)-2-((S)-2-(6-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Hexanamido)-3-Methylbutanamido)-5-Ureidopentanoicacid is a high-purity, synthetic amino acid derivative featuring a maleimide functional group. This compound is critical for advanced bioconjugation and linker chemistry, enabling the site-specific attachment of biomolecules, peptides, or drug payloads. It is primarily utilized by researchers and manufacturers in pharmaceutical development, proteomics, and the production of antibody-drug conjugates (ADCs) and other targeted therapeutics.

Application

• Bioconjugation Reagent: Key component for the covalent, site-specific labeling of proteins, antibodies, and peptides via thiol-maleimide chemistry.
• Antibody-Drug Conjugate (ADC) Linker: Serves as a sophisticated chemical handle in the synthesis of cleavable or non-cleavable linkers for targeted cancer therapies.
• Proteomics Research: Used in the design of activity-based probes (ABPs) and for the stable immobilization of biomolecules on solid supports.
• Peptide Engineering: Incorporated into synthetic peptides to introduce functional handles for further modification or cross-linking studies.
• Diagnostic Reagent Development: Employed in the creation of fluorescent or enzyme-labeled conjugates for immunoassays and diagnostic kits.
• Polymer and Material Science: Acts as a functional monomer or cross-linker for creating smart polymers with bioactive surfaces.

Basic Information

Product Name	(S)-2-((S)-2-(6-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Hexanamido)-3-Methylbutanamido)-5-Ureidopentanoicacid
CAS No.	916746-27-5
Molecular Formula	C21H33N5O7
Molecular Weight	467.52 g/mol
Synonyms	N6-(6-Maleimidocaproyl)-L-lysyl-L-valine; Maleimidocaproyl-Lys-Val; MC-Lys-Val; L-Valine, N2-[N6-(6-maleimidocaproyl)-L-lysyl]-; Nα-(Nε-(6-Maleimidocaproyl)-L-lysyl)-L-valine; Valine-Lysine(Maleimidocaproyl); ADC Linker Amino Acid; Val-Lys(Mal)
EINECS	Contact for details

Quality Control

Our (S)-2-((S)-2-(6-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Hexanamido)-3-Methylbutanamido)-5-Ureidopentanoicacid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container sealed in a secondary, moisture-proof barrier. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.