Description

Rolapitant Hydrochloride CAS NO 914462-92-3 is a high-purity, small-molecule active pharmaceutical ingredient (API) belonging to the class of neurokinin-1 (NK1) receptor antagonists. This compound is critical for the formulation of antiemetic medications used to prevent chemotherapy-induced nausea and vomiting (CINV). It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of advanced oncology support therapies and novel central nervous system (CNS) formulations.

Application

• Primary API in the manufacture of oral antiemetic drugs for the prevention of acute and delayed CINV.
• Key ingredient in pharmaceutical research and development for new neurokinin-1 receptor antagonist formulations.
• Reference standard for analytical method development and validation in quality control laboratories.
• Starting material or intermediate for the synthesis of related chemical entities in medicinal chemistry.
• Active component in non-clinical and clinical trial materials for investigational new drugs (INDs).
• Used in studies exploring potential applications in other CNS-related disorders.

Basic Information

Product Name	Rolapitant Hydrochloride
CAS No.	914462-92-3
Molecular Formula	C31H41ClFNO4
Molecular Weight	546.12 g/mol
Synonyms	Rolapitant HCl; Varubi (Brand Name); (5S,8S)-8-{[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one Hydrochloride; SCH 619734; Rolapitant Monohydrochloride; NK-1 Receptor Antagonist Rolapitant HCl; 1,7-Diazaspiro[4.5]decan-2-one, 8-[[[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-, hydrochloride, (5S,8S)-
EINECS	Contact for details

Quality Control

Our Rolapitant Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) documenting compliance with relevant standards are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.