Description

n-Acetyl-S-[n-(2-Phenyl-D5-Ethyl)Thiocarbamoyl]-L-Cysteine is a deuterated, stable isotope-labeled derivative of a key cysteine metabolite. This compound is specifically engineered for use as an internal standard in advanced analytical techniques, providing unmatched accuracy and reliability for quantitative analysis. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise measurement of metabolic pathways and drug-related compounds.

Application

• Primary use as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for quantitative bioanalysis.
• Critical for pharmacokinetic (PK) and toxicokinetic (TK) studies to accurately measure drug metabolites and biomarkers in biological matrices like plasma, urine, and tissue.
• Enables high-precision research in metabolomics and proteomics for pathway analysis and biomarker discovery.
• Supports drug development and regulatory submissions by providing data that meets stringent FDA and EMA guidelines for bioanalytical method validation.
• Used in environmental and food safety testing for the trace-level detection of specific contaminants or residues.
• Facilitates clinical diagnostics research for developing assays related to sulfur amino acid metabolism disorders.

Basic Information

Product Name	n-Acetyl-S-[n-(2-Phenyl-D5-Ethyl)Thiocarbamoyl]-L-Cysteine
CAS No.	912628-02-5
Molecular Formula	C₁₄H₁₀D₅N₂O₃S₂
Molecular Weight	Approx. 342.46 g/mol
Synonyms	N-Acetyl-S-(N-2-phenylethylthiocarbamoyl)-L-cysteine-d5; Acetylcysteine-d5 mercapturic acid derivative; L-Cysteine, N-acetyl-S-[N-[(2,2,3,3,4,4,5,5,6,6-d10)hexyl]carbamothioyl]-; Deuterated N-Acetyl-S-phenylpropylcysteine; AAMA-d5 (2-Carbamoyl-2-hydroxyethyl-d5 mercapturic acid analog); Stable Isotope Labeled Cysteine Metabolite; Internal Standard for Mercapturic Acid Analysis; Deuterated NAC Conjugate
EINECS	Contact for details

Quality Control

Every batch of our deuterated internal standards is produced and analyzed under strict quality management to ensure isotopic purity, chemical purity, and batch-to-batch consistency essential for reliable quantitative analysis. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (e.g., D5, >98 atom % D), chemical purity (by HPLC, typically ≥95%), and confirmatory data from NMR and MS. Our quality systems support compliance with ISO 9001 standards and meet the rigorous demands of GLP/GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to maintain purity and prevent degradation. Allow the vial to equilibrate to room temperature in a dry environment before opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity	≥ 98 atom % D (D5)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.